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【双语课堂】柚汁与葡萄柚汁影响药物的作用
2010-11-23 08:36 丁香园 albmu  发布范围:公开
Ask the doctor: Does pomelo juice affect drugs the same way grapefruit juice does?

咨询医生:柚子汁影响药物的方式是否与葡萄柚汁相同?

Q. I avoid grapefruit juice because my doctor says it affects how my body handles the Lipitor I take for my cholesterol. Should I also stay away from pomelo?

问:我避开葡萄柚汁,因为我的医生说它影响我的身体如何对待我为了血脂服用的立普妥。我是否也应该远离柚子?

A. The pomelo (also called shaddock, pumelo, pommelo, and Chinese grapefruit) is the largest citrus fruit, ranging from the size of a cantaloupe to that of a large watermelon. Botanists believe that crosses between pomelo and wild orange created grapefruit.

答:柚子(也叫做文旦、柚子、柚和中国柚子)是最大的柑橘属水果,大小从哈密瓜到大西瓜。植物学家相信柚子和野生桔子的杂交产生了葡萄柚。

Pomelo mixes the sweet taste of orange with the tang of lemon. Its lineage means that pomelo contains many of the same compounds as grapefruit.

柚子混合了桔子的甜味和柠檬的味道。它的传承意味着柚子包含很多与葡萄柚相同的成分。

One or more substances in grapefruit and grapefruit juice block the action of an enzyme called cytochrome P-450 3A4 (CYP3A4). This enzyme breaks down a wide array of medications, including atorvastatin (Lipitor). (For an extensive list of drugs affected by grapefruit juice, visit health.harvard.edu/165.)

葡萄柚和葡萄柚汁中一种或更多的成分阻碍了叫做一种细胞色素P-450 3A4酶的活性。这种酶破坏一系列药物,包括阿托伐他汀(立普妥)。

Knocking CYP3A4 out of action means higher blood levels of these medications. One glass of grapefruit juice, or eating half a grapefruit, is enough to suppress CYP3A4 activity by half, and the effect lasts up to 24 hours. The accumulation of active statin in the bloodstream could cause muscle or liver problems.

使CYP3A4失效意味着这些药物更高的血液水平。一杯葡萄柚汁或吃半个葡萄柚足够抑制CYP3A4活性的一半,并且这种效应持续达24小时。血管中活性他汀的积聚能够导致肌肉和肝脏疾病。

From the handful of studies on the effects of pomelo on drug metabolism, it looks like pomelo and pomelo juice act much like grapefruit and grapefruit juice.

根据少数关于柚子对药物代谢影响的研究,看起来柚子和柚子汁像葡萄柚和葡萄柚汁一样起作用。

Grapefruit and pomelo aren't the only fruits that affect drug metabolism. Lab studies suggest that black mulberry juice, wild grape juice, pomegranate juice, and black raspberry juice also interfere with CYP3A4.

葡萄柚和柚子不是影响药物代谢的唯一水果。实验室研究表明黑果桑木汁、野葡萄汁、石榴汁和黑莓汁也影响CYP3A4。

You have two basic options. One is to avoid eating pomelo and drinking juice made from it. The other is to keep enjoying it but talk with your doctor about switching to a statin that isn't affected by grapefruit, such as fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), or rosuvastatin (Crestor).

你有两个基本选择。一个是避免吃柚子和和由它生产的果汁。另一个是继续享用它,但是与你的医生讨论转换一种不受葡萄柚影响的他汀类药,例如氟伐他汀、匹伐他汀、普伐他汀或罗苏伐他汀。
 
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