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【双语快讯】大豆异黄酮和内分泌辅助治疗乳腺癌患者
2010-11-18 08:40 丁香园 crazyboy78  发布范围:公开
Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy.
大豆异黄酮对内分泌辅助治疗乳腺癌患者复发和死亡的影响

BACKGROUND: The intake of soy isoflavones among women with breast cancer has become a public health concern, because these compounds have weak estrogenic effects. There is little clinical evidence about their safety for patients with breast cancer who are receiving adjuvant endocrine therapy.
研究背景:女性乳腺癌患者摄入大豆异黄酮之所以成为公共卫生议题,是因为这些化合物有微弱雌激素样作用。正接受内分泌辅助治疗的乳腺癌患者摄入大豆异黄酮的安全性鲜有临床报道。

METHODS: For patients who underwent surgery for breast cancer between August 2002 and July 2003 and who were receiving adjuvant endocrine therapy, we examined associations between dietary intake of soy isoflavones and recurrence of breast cancer and death. We measured dietary intake of soy isoflavones at baseline using a validated food frequency questionnaire. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) by means of multivariable Cox proportional hazards regression models. We further stratified the analyses by hormonal receptor status and endocrine therapy.
方法:从2002年8月到2003年7月,接受内分泌辅助治疗的乳腺癌手术患者参与了这一研究。我们研究了患者饮食摄入大豆异黄酮水平和乳腺癌复发、死亡之间的关系。在基线水平时,我们用食物频率调查表调查了饮食中大豆异黄酮的摄入水平。通过构建多变量Cox累计风险比例回归模型,我们计算了风险比(HRs)和95%置信区间(CIs)。根据激素受体和内分治疗状况,我们进一步做了分层分析。

RESULTS: The median follow-up period for the 524 patients in this study was 5.1 years. Among premenopausal patients, the overall death rate (30.6%) was not related to intake of soy isoflavones (HR = 1.05, 95% CI 0.78-1.71 for the highest quartile [> 42.3 mg/day] v. the lowest quartile [< 15.2 mg/day], p for trend = 0.87). Relative to postmenopausal patients in the lowest quartile of soy isoflavone intake, the risk of recurrence for postmenopausal patients in the highest quartile was significantly lower (HR = 0.67, 95% CI 0.54-0.85, p for trend = 0.02). Inverse associations were observed in patients with estrogen and progesterone receptor positive disease and those receiving anastrozole therapy.
结果:524例患者的中位随访时间为5.1年。绝经前患者总死亡率(30.6%)和大豆异黄酮摄入水平无关联(最高四分位水平[> 42.3 mg/day] v.最低四分位水平[< 15.2 mg/day]HR = 1.05, 95% CI 0.78-1.71, 趋势分析p = 0.87)。相对于最低四分位大豆异黄酮摄入水平的绝经后患者,最高四分位大豆异黄酮摄入水平的绝经后患者复发风险显著降低(HR = 0.67, 95% CI 0.54-0.85, 趋势分析p = 0.02)。雌、孕激素受体阳性患者和阿那曲唑治疗患者也出现类似结果。

INTERPRETATION: High dietary intake of soy isoflavones was associated with lower risk of recurrence among postmenopausal patients with breast cancer positive for estrogen and progesterone receptor and those who were receiving anastrozole as endocrine therapy.
结论:绝经后、接受阿那曲唑治疗及雌、孕激素受体阳性乳腺癌患者,大豆异黄酮饮食高摄入与低复发风险相关。
 

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